4ldr

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Template:STRUCTURE 4ldr

Contents

Structure of the S283Y mutant of MRDI

Template:ABSTRACT PUBMED 23859498

Function

[MTNA_HUMAN] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.[1]

About this Structure

4ldr is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Templeton PD, Litman ES, Metzner SI, Ahn NG, Sousa MC. Structure of MRDI Explains its Dual Function as a Metabolic Enzyme and a Mediator of Cell Invasion. Biochemistry. 2013 Jul 16. PMID:23859498 doi:10.1021/bi400556e
  1. ↑ Kabuyama Y, Litman ES, Templeton PD, Metzner SI, Witze ES, Argast GM, Langer SJ, Polvinen K, Shellman Y, Chan D, Shabb JB, Fitzpatrick JE, Resing KA, Sousa MC, Ahn NG. A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme. Mol Cell Proteomics. 2009 Oct;8(10):2308-20. doi: 10.1074/mcp.M900178-MCP200., Epub 2009 Jul 20. PMID:19620624 doi:10.1074/mcp.M900178-MCP200

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