3aoa

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Template:STRUCTURE 3aoa

Contents 1 Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket 2 Function 3 About this Structure 4 Reference

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

Template:ABSTRACT PUBMED 22121023

Function

[ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.^{[1] [2] [3]}

About this Structure

3aoa is a 3 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

• Nakashima R, Sakurai K, Yamasaki S, Nishino K, Yamaguchi A. Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket. Nature. 2011 Nov 27;480(7378):565-9. doi: 10.1038/nature10641. PMID:22121023 doi:10.1038/nature10641

1. ↑ Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature. 2006 Sep 14;443(7108):173-9. Epub 2006 Aug 16. PMID:16915237 doi:10.1038/nature05076
2. ↑ Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM. Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science. 2006 Sep 1;313(5791):1295-8. PMID:16946072 doi:313/5791/1295
3. ↑ Sennhauser G, Amstutz P, Briand C, Storchenegger O, Grutter MG. Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol. 2007 Jan;5(1):e7. PMID:17194213 doi:10.1371/journal.pbio.0050007