4j74

From Proteopedia

Revision as of 20:53, 7 August 2013 by OCA (Talk | contribs)
Jump to: navigation, search

Template:STRUCTURE 4j74

Contents

The 1.2A crystal structure of humanized Xenopus MDM2 with RO0503918 - a nutlin fragment

Template:ABSTRACT PUBMED 14704432

Function

[MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).

About this Structure

4j74 is a 1 chain structure with sequence from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

  • Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu EA. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004 Feb 6;303(5659):844-8. Epub 2004 Jan 2. PMID:14704432 doi:10.1126/science.1092472

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4j74"
Personal tools