3ope

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 3ope

Contents 1 Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase 2 Function 3 About this Structure 4 Reference

Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase

Template:ABSTRACT PUBMED 21239497

Function

[ASH1L_HUMAN] Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).^[1]

About this Structure

3ope is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• An S, Yeo KJ, Jeon YH, Song JJ. Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism. J Biol Chem. 2011 Mar 11;286(10):8369-74. Epub 2011 Jan 14. PMID:21239497 doi:10.1074/jbc.M110.203380

1. ↑ An S, Yeo KJ, Jeon YH, Song JJ. Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism. J Biol Chem. 2011 Mar 11;286(10):8369-74. Epub 2011 Jan 14. PMID:21239497 doi:10.1074/jbc.M110.203380