This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3vw7
From Proteopedia
Contents |
Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom
Template:ABSTRACT PUBMED 23222541
Function
[PAR1_HUMAN] High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.[1]
About this Structure
3vw7 is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK. High-resolution crystal structure of human protease-activated receptor 1. Nature. 2012 Dec 20;492(7429):387-92. doi: 10.1038/nature11701. Epub 2012 Dec 9. PMID:23222541 doi:10.1038/nature11701
- ↑ Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar;103(6):879-87. PMID:10079109 doi:10.1172/JCI6042
Categories: Lysozyme | Arlow, D H. | Coughlin, S R. | Dror, R O. | Fung, J J. | Green, H F. | Kobilka, B K. | Palmer, D. | Pandey, A. | Shaw, D E. | Srinivasan, Y. | Weis, W I. | Zhang, C. | Zheng, Y. | Antagonist vorapaxar | G protein-coupled receptor | High resolution structure | Inactive conformation | Membrane protein | Protease-activated receptor 1 | Signaling protein | Signaling protein-antagonist complex | Thrombin receptor-antagonist complex
