1vzm
From Proteopedia
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OSTEOCALCIN FROM FISH ARGYROSOMUS REGIUS
Overview
Osteocalcin is a small (45 amino acids) secreted protein found to, accumulate in bone and dentin of many organisms by interacting with, calcium and hydroxyapatite, through the presence of three, gamma-carboxylated residues. In this work, we describe the first X-ray, crystal structure for a nonmammalian osteocalcin, obtained at 1.4 A, resolution, purified from the marine teleost fish Argyrosomus regius. The, three-dimensional fit between the A. regius structure and that of the only, other known X-ray structure, the porcine osteocalcin, revealed a, superposition of the Calpha atoms of their metal chelating residues, Gla, and Asp, showing that their spatial distribution is consistent with the, interatomic distances of calcium cations in the hydroxyapatite crystals., In both structures, the ... [(full description)]
About this Structure
1VZM is a [Single protein] structure of sequence from [Argyrosomus regius] with MG as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural evidence of a fourth Gla residue in fish osteocalcin: biological implications., Frazao C, Simes DC, Coelho R, Alves D, Williamson MK, Price PA, Cancela ML, Carrondo MA, Biochemistry. 2005 Feb 1;44(4):1234-42. PMID:15667217
Page seeded by OCA on Tue Oct 30 16:20:17 2007
