C-di-GMP receptors with PilZ domain

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spinqualitylabelsall models PDB ID 1yln Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image PlzD (1yln). from Vibrio cholerae is composed of a and a C-terminal domain (with very similar fold). The c-di-GMP is formed by arginine residues of the inter-domain linker and the PlzD domain surface . PlzD in complex with c-di-GMP (2rde). Upon complex formation the relative domain arrangement is (compare with 1yln above), see also .

References

PlzD structure 1yln:

• Zhang R, Zhou M, Moy S, Collart FR, Joachimiak A. 2005. The crystal structure of

the hypothetical protein vca0042 from Vibrio cholerae O1. Midwest Center of Structural Genomics (MCSG).

PlzD - c-di-GMP structure 2rde:

• Benach J, Swaminathan SS, Tamayo R, Handelman SK, Folta-Stogniew E, Ramos JE, Forouhar F, Neely H, Seetharaman J, Camilli A, Hunt JF. The structural basis of cyclic diguanylate signal transduction by PilZ domains. EMBO J. 2007 Dec 12;26(24):5153-66. Epub 2007 Nov 22. PMID:18034161