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Sandbox Mati

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Revision as of 19:43, 27 August 2013 by Mati Cohen (Talk | contribs)
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Bcl-Xl is a member of the Bcl-2 family . This family consists of pro-apoptotic and anti-apoptotic members. Bcl-Xl as can be seen in the image

Bcl-Xl and ABT737 from PDBID 2yxj

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.an anti a poptotivc protein binds pro apoptotic proteins like BAK and BAD thus inhibiting program cell death. Many cancer cells overexpress at least one of the anti-apoptotic members of this family , thus escaping apoptosis . Therefore these proteins are important targets for the development of new anti-cancer drugs.
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