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Sandbox Mati

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Revision as of 19:45, 27 August 2013 by Mati Cohen (Talk | contribs)
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Bcl-Xl is a member of the Bcl-2 family . This family consists of pro-apoptotic and anti-apoptotic members. Bcl-Xl(in the image)

Bcl-Xl and ABT737 from PDB-ID 2yxj

Drag the structure with the mouse to rotate
,an anti apoptotic protein, binds pro apoptotic proteins like BAK and BAD thus inhibiting program cell death. Many cancer cells overexpress at least one of the anti-apoptotic members of this family , thus escaping apoptosis . Therefore these proteins are important targets for the development of new anti-cancer drugs.
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