We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

Sandbox Mati

From Proteopedia

Revision as of 20:15, 27 August 2013 by Mati Cohen (Talk | contribs)
Jump to: navigation, search
Bcl-Xl is a member of the Bcl-2 family . This family consists of pro-apoptotic and anti-apoptotic members. Bcl-Xl(in the image)

Bcl-Xl and ABT737 from PDB-ID 2yxj

Drag the structure with the mouse to rotate
,an anti apoptotic protein, binds pro apoptotic proteins like BAK and BAD thus inhibiting program cell death. Many cancer cells overexpress at least one of the anti-apoptotic members of this family , thus escaping apoptosis . Therefore these proteins are important targets for the development of new anti-cancer drugs.

the PDB file 2yxjshows the structure of Bcl-Xl and ABT 737. ABT 737 is a sub nano Molar inhibitor of Bcl-Xl. It binds Bcl-xl in the same position as BAK does as can be seen in 1bxl. Interestingly the interface of Bcl-Xl is almost symmetric.

Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_Mati"
Personal tools