3tzb

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Template:STRUCTURE 3tzb

Contents

Quinone Oxidoreductase (NQ02) bound to NSC13000

Template:ABSTRACT PUBMED 22090421

Function

[NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.[1]

About this Structure

3tzb is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Nolan KA, Dunstan MS, Caraher MC, Scott KA, Leys D, Stratford IJ. In silico screening reveals structurally diverse, nanomolar inhibitors of NQO2 that are functionally active in cells and can modulate NF-kappaB signaling. Mol Cancer Ther. 2012 Jan;11(1):194-203. doi: 10.1158/1535-7163.MCT-11-0543. Epub, 2011 Nov 16. PMID:22090421 doi:10.1158/1535-7163.MCT-11-0543
  1. ↑ Calamini B, Santarsiero BD, Boutin JA, Mesecar AD. Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. Biochem J. 2008 Jul 1;413(1):81-91. PMID:18254726 doi:10.1042/BJ20071373

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