4jkt

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Template:STRUCTURE 4jkt

Contents

Crystal structure of mouse Glutaminase C, BPTES-bound form

Template:ABSTRACT PUBMED 23935106

Function

[GLSK_MOUSE] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain.[1] [2] [3]

About this Structure

4jkt is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Ferreira AP, Cassago A, Goncalves KA, Dias MM, Adamoski D, Ascencao CF, Honorato RV, de Oliveira JF, Ferreira IM, Fornezari C, Bettini J, Oliveira PS, Paes Leme AF, Portugal RV, Ambrosio AL, Dias SM. Active Glutaminase C self-assembles into a supra-tetrameric oligomer which can be disrupted by an allosteric inhibitor. J Biol Chem. 2013 Aug 8. PMID:23935106 doi:10.1074/jbc.M113.501346
  1. ↑ Masson J, Darmon M, Conjard A, Chuhma N, Ropert N, Thoby-Brisson M, Foutz AS, Parrot S, Miller GM, Jorisch R, Polan J, Hamon M, Hen R, Rayport S. Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth. J Neurosci. 2006 Apr 26;26(17):4660-71. PMID:16641247 doi:10.1523/JNEUROSCI.4241-05.2006
  2. ↑ El Hage M, Masson J, Conjard-Duplany A, Ferrier B, Baverel G, Martin G. Brain slices from glutaminase-deficient mice metabolize less glutamine: a cellular metabolomic study with carbon 13 NMR. J Cereb Blood Flow Metab. 2012 May;32(5):816-24. doi: 10.1038/jcbfm.2012.22. Epub, 2012 Feb 29. PMID:22373647 doi:10.1038/jcbfm.2012.22
  3. ↑ Cassago A, Ferreira AP, Ferreira IM, Fornezari C, Gomes ER, Greene KS, Pereira HM, Garratt RC, Dias SM, Ambrosio AL. Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1092-7. Epub 2012 Jan 6. PMID:22228304 doi:10.1073/pnas.1112495109

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