4krv

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Template:STRUCTURE 4krv

Contents

Crystal structure of catalytic domain of bovine beta1,4-galactosyltransferase mutant M344H-GalT1 complex with 6-sulfo-GlcNAc

Template:ABSTRACT PUBMED 23942731

Function

[B4GT1_BOVIN] The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.

About this Structure

4krv is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  • Ramakrishnan B, Moncrief AJ, Davis TA, Holland LA, Qasba PK. Investigations on beta1,4-galactosyltransferase I using 6-sulfo-GlcNAc as an acceptor sugar substrate. Glycoconj J. 2013 Aug 13. PMID:23942731 doi:10.1007/s10719-013-9488-4

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