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3u6w

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Revision as of 08:46, 4 September 2013 by OCA (Talk | contribs)
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Template:STRUCTURE 3u6w

Contents

Truncated M. tuberculosis LeuA (1-425) complexed with KIV

Template:ABSTRACT PUBMED 22352945

Function

[LEU1_MYCTU] Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity).

About this Structure

3u6w is a 2 chain structure with sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA.

Reference

  • Huisman FH, Koon N, Bulloch EM, Baker HM, Baker EN, Squire CJ, Parker EJ. Removal of the C-Terminal Regulatory Domain of alpha-Isopropylmalate Synthase Disrupts Functional Substrate Binding. Biochemistry. 2012 Mar 6. PMID:22352945 doi:10.1021/bi201717j

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OCA

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