3u1c

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Template:STRUCTURE 3u1c

Contents

Anti-parallel dimer of N-terminal 98-aa fragment of smooth muscle tropomyosin alpha

Template:ABSTRACT PUBMED 22119916

Function

[TPM1_CHICK] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

About this Structure

3u1c is a 2 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA.

See Also

Reference

  • Rao JN, Rivera-Santiago R, Li XE, Lehman W, Dominguez R. Structural analysis of smooth muscle tropomyosin alpha and beta isoforms. J Biol Chem. 2012 Jan 27;287(5):3165-74. Epub 2011 Nov 27. PMID:22119916 doi:10.1074/jbc.M111.307330

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