4fuw

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Template:STRUCTURE 4fuw

Contents 1 Crystal structure of Ego3 mutant 2 Function 3 About this Structure 4 Reference

Crystal structure of Ego3 mutant

Template:ABSTRACT PUBMED 23123112

Function

[SLM4_YEAST] Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome. Component of the EGO complex, a complex involved in the regulation of microautophagy.^{[1] [2]}

About this Structure

4fuw is a 2 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

• Zhang T, Peli-Gulli MP, Yang H, De Virgilio C, Ding J. Ego3 Functions as a Homodimer to Mediate the Interaction between Gtr1-Gtr2 and Ego1 in the EGO Complex to Activate TORC1. Structure. 2012 Oct 30. pii: S0969-2126(12)00372-3. doi:, 10.1016/j.str.2012.09.019. PMID:23123112 doi:10.1016/j.str.2012.09.019

1. ↑ Dubouloz F, Deloche O, Wanke V, Cameroni E, De Virgilio C. The TOR and EGO protein complexes orchestrate microautophagy in yeast. Mol Cell. 2005 Jul 1;19(1):15-26. PMID:15989961 doi:10.1016/j.molcel.2005.05.020
2. ↑ Gao M, Kaiser CA. A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast. Nat Cell Biol. 2006 Jul;8(7):657-67. Epub 2006 May 28. PMID:16732272 doi:ncb1419