4ee2

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Template:STRUCTURE 4ee2

Contents

Crystal Structure of Anthrax Protective Antigen K446M Mutant to 1.91-A Resolution

Template:ABSTRACT PUBMED 23100533

Function

[PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.

About this Structure

4ee2 is a 1 chain structure with sequence from Bacillus anthracis. Full crystallographic information is available from OCA.

Reference

  • Kintzer AF, Tang II, Schawel AK, Brown MJ, Krantz BA. Anthrax toxin protective antigen integrates poly-gamma-D-glutamate and pH signals to sense the optimal environment for channel formation. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18378-83. doi:, 10.1073/pnas.1208280109. Epub 2012 Oct 24. PMID:23100533 doi:10.1073/pnas.1208280109

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