4ika

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Template:STRUCTURE 4ika

Contents 1 Crystal structure of EV71 3Dpol-VPg 2 Function 3 About this Structure 4 Reference

Crystal structure of EV71 3Dpol-VPg

Template:ABSTRACT PUBMED 23487447

Function

[Q0ZSY4_9ENTO] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]

About this Structure

4ika is a 2 chain structure with sequence from Enterovirus a71. Full crystallographic information is available from OCA.

Reference

• Chen C, Wang Y, Shan C, Sun Y, Xu P, Zhou H, Yang C, Shi PY, Rao Z, Zhang B, Lou Z. Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: implication for a trans mechanism of VPg uridylylation. J Virol. 2013 May;87(10):5755-68. doi: 10.1128/JVI.02733-12. Epub 2013 Mar 13. PMID:23487447 doi:10.1128/JVI.02733-12