4jvm
From Proteopedia
Contents |
Crystal structure of human estrogen sulfotransferase (SULT1E1) in complex with inactive cofactor PAP and brominated flame retardant TBBPA (tetrabromobisphenol A)
Template:ABSTRACT PUBMED 23959441
Function
[ST1E1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.[1]
About this Structure
4jvm is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Gosavi RA, Knudsen GA, Birnbaum LS, Pedersen LC. Mimicking of Estradiol Binding by Flame Retardants and Their Metabolites: A Crystallographic Analysis. Environ Health Perspect. 2013 Aug 19. PMID:23959441 doi:10.1289/ehp.1306902
- ↑ Pedersen LC, Petrotchenko E, Shevtsov S, Negishi M. Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction. J Biol Chem. 2002 May 17;277(20):17928-32. Epub 2002 Mar 7. PMID:11884392 doi:http://dx.doi.org/10.1074/jbc.M111651200
