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4b8e
From Proteopedia
PRY-SPRY domain of Trim25
Function
[TRI25_MOUSE] Functions as an ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs (By similarity).
About this Structure
4b8e is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
