4fbt

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Template:STRUCTURE 4fbt

Contents 1 Dpo4 post-insertion complex with the N-(deoxyguanosin-8-yl)-1-aminopyrene lesion 2 Function 3 About this Structure 4 See Also 5 Reference

Dpo4 post-insertion complex with the N-(deoxyguanosin-8-yl)-1-aminopyrene lesion

Template:ABSTRACT PUBMED 23876706

Function

[DPO4_SULSO] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.[HAMAP-Rule:MF_01113]

About this Structure

4fbt is a 3 chain structure with sequence from Sulfolobus solfataricus p2. Full crystallographic information is available from OCA.

See Also

• DNA polymerase

Reference

• Kirouac KN, Basu AK, Ling H. Structural Mechanism of Replication Stalling on a Bulky Amino-Polycyclic Aromatic Hydrocarbon DNA Adduct by a Y Family DNA Polymerase. J Mol Biol. 2013 Jul 20. pii: S0022-2836(13)00454-3. doi:, 10.1016/j.jmb.2013.07.020. PMID:23876706 doi:10.1016/j.jmb.2013.07.020