4k2p

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Template:STRUCTURE 4k2p

Contents

The Structure of a Quintuple Mutant of the Tiam1 PH-CC-Ex Domain

Template:ABSTRACT PUBMED 23832200

Function

[TIAM1_HUMAN] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.

About this Structure

4k2p is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Joshi M, Gakhar L, Fuentes EJ. High-resolution structure of the Tiam1 PHn-CC-Ex domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jul;69(Pt 7):744-52. doi: , 10.1107/S1744309113014206. Epub 2013 Jun 27. PMID:23832200 doi:10.1107/S1744309113014206

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