3o2f

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 3o2f

Contents 1 Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54 2 Function 3 About this Structure 4 See Also 5 Reference

Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54

Template:ABSTRACT PUBMED 23995768

Function

[ENPL_CANFA] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).

About this Structure

3o2f is a 2 chain structure with sequence from Canis lupus familiaris. Full crystallographic information is available from OCA.

See Also

• Endoplasmin

Reference

• Patel PD, Yan P, Seidler PM, Patel HJ, Sun W, Yang C, Que NS, Taldone T, Finotti P, Stephani RA, Gewirth DT, Chiosis G. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat Chem Biol. 2013 Sep 1. doi: 10.1038/nchembio.1335. PMID:23995768 doi:10.1038/nchembio.1335