3v61

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Template:STRUCTURE 3v61

Contents

Structure of S. cerevisiae PCNA conjugated to SUMO on lysine 164

Template:ABSTRACT PUBMED 22382979

Function

[SMT3_YEAST] Not known; suppressor of MIF2 mutations. [PCNA_YEAST] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.[1] [2]

About this Structure

3v61 is a 2 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

See Also

Reference

  • Armstrong AA, Mohideen F, Lima CD. Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2. Nature. 2012 Feb 29;483(7387):59-63. doi: 10.1038/nature10883. PMID:22382979 doi:10.1038/nature10883
  1. ↑ Haracska L, Kondratick CM, Unk I, Prakash S, Prakash L. Interaction with PCNA is essential for yeast DNA polymerase eta function. Mol Cell. 2001 Aug;8(2):407-15. PMID:11545742
  2. ↑ Hoege C, Pfander B, Moldovan GL, Pyrowolakis G, Jentsch S. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature. 2002 Sep 12;419(6903):135-41. PMID:12226657 doi:10.1038/nature00991

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