3l9k

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Template:STRUCTURE 3l9k

Contents 1 Insights into dynein assembly from a dynein intermediate chain-light chain roadblock structure 2 Function 3 About this Structure 4 See Also 5 Reference

Insights into dynein assembly from a dynein intermediate chain-light chain roadblock structure

Function

[DYIN_DROME] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the help dynein bind to dynactin 150 kDa component (By similarity).^[1]

About this Structure

3l9k is a 8 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

See Also

• Dynein

Reference

• Hall J, Song Y, Karplus PA, Barbar E. The crystal structure of dynein intermediate chain-light chain roadblock complex gives new insights into dynein assembly. J Biol Chem. 2010 Jul 16;285(29):22566-75. Epub 2010 May 15. PMID:20472935 doi:10.1074/jbc.M110.103861

1. ↑ Boylan K, Serr M, Hays T. A molecular genetic analysis of the interaction between the cytoplasmic dynein intermediate chain and the glued (dynactin) complex. Mol Biol Cell. 2000 Nov;11(11):3791-803. PMID:11071907