2m9m

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Template:STRUCTURE 2m9m

Contents

Solution Structure of ERCC4 domain of human FAAP24

Template:ABSTRACT PUBMED 23999858

Function

[FAP24_HUMAN] Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.

About this Structure

2m9m is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Wang Y, Han X, Wu F, Leung JW, Lowery MG, Do H, Chen J, Shi C, Tian C, Li L, Gong W. Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response. Cell Res. 2013 Sep 3. doi: 10.1038/cr.2013.124. PMID:23999858 doi:10.1038/cr.2013.124

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