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4m5v

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Revision as of 04:13, 20 September 2013 by OCA (Talk | contribs)
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Template:STRUCTURE 4m5v

Contents

Influenza 2009 H1N1 endonuclease with 100 millimolar calcium

Template:ABSTRACT PUBMED 23978130

Function

[F0TRT1_9INFA] Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication (By similarity).[SAAS:SAAS001009_004_020464]

About this Structure

4m5v is a 1 chain structure with sequence from Influenza a virus (a/lima/wrair1695p/2009(h1n1)). Full crystallographic information is available from OCA.

Reference

  • Bauman JD, Patel D, Baker SF, Vijayan RS, Xiang A, Parhi AK, Martinez-Sobrido L, Lavoie EJ, Das K, Arnold E. Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors. ACS Chem Biol. 2013 Sep 13. PMID:23978130 doi:10.1021/cb400400j

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OCA

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