3bt7

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Template:STRUCTURE 3bt7

Contents 1 Structure of E. coli 5-Methyluridine Methyltransferase TrmA in complex with 19 nucleotide T-arm analogue 2 Function 3 About this Structure 4 Reference

Structure of E. coli 5-Methyluridine Methyltransferase TrmA in complex with 19 nucleotide T-arm analogue

Template:ABSTRACT PUBMED 18451029

Function

[TRMA_ECOLI] Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs.^{[1] [2]}

About this Structure

3bt7 is a 4 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

• Alian A, Lee TT, Griner SL, Stroud RM, Finer-Moore J. Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases. Proc Natl Acad Sci U S A. 2008 May 13;105(19):6876-81. Epub 2008 May 1. PMID:18451029

1. ↑ Ny T, Bjork GR. Cloning and restriction mapping of the trmA gene coding for transfer ribonucleic acid (5-methyluridine)-methyltransferase in Escherichia coli K-12. J Bacteriol. 1980 May;142(2):371-9. PMID:6247318
2. ↑ Lindstrom PH, Stuber D, Bjork GR. Genetic organization and transcription from the gene (trmA) responsible for synthesis of tRNA (uracil-5)-methyltransferase by Escherichia coli. J Bacteriol. 1985 Dec;164(3):1117-23. PMID:2999071