3ax9

From Proteopedia

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Template:STRUCTURE 3ax9

Contents 1 Bovine xanthine oxidase, protease cleaved form 2 Function 3 About this Structure 4 See Also 5 Reference

Bovine xanthine oxidase, protease cleaved form

Template:ABSTRACT PUBMED 22145797

Function

[XDH_BOVIN] Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.

About this Structure

3ax9 is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

See Also

• Xanthine dehydrogenase

Reference

• Ishikita H, Eger BT, Okamoto K, Nishino T, Pai EF. Protein conformational gating of enzymatic activity in xanthine oxidoreductase. J Am Chem Soc. 2012 Jan 18;134(2):999-1009. Epub 2011 Dec 29. PMID:22145797 doi:http://dx.doi.org/10.1021/ja207173p