3kl4

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Template:STRUCTURE 3kl4

Contents

Recognition of a signal peptide by the signal recognition particle

Template:ABSTRACT PUBMED 20364120

Function

[SRP54_SULSO] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity).

About this Structure

3kl4 is a 2 chain structure with sequence from Saccharomyces cerevisiae and Sulfolobus solfataricus p2. Full crystallographic information is available from OCA.

Reference

  • Janda CY, Li J, Oubridge C, Hernandez H, Robinson CV, Nagai K. Recognition of a signal peptide by the signal recognition particle. Nature. 2010 May 27;465(7297):507-10. Epub 2010 Apr 4. PMID:20364120 doi:10.1038/nature08870

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