4btj

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Template:STRUCTURE 4btj

Contents 1 TTBK1 in complex with ATP 2 Function 3 About this Structure 4 Reference

TTBK1 in complex with ATP

Template:ABSTRACT PUBMED 24039150

Function

[TTBK1_HUMAN] Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.^[1]

About this Structure

4btj is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Xue Y, Wan PT, Hillertz P, Schweikart F, Zhao Y, Wissler L, Dekker N. X-ray Structural Analysis of Tau-Tubulin Kinase 1 and Its Interactions with Small Molecular Inhibitors. ChemMedChem. 2013 Sep 13. doi: 10.1002/cmdc.201300274. PMID:24039150 doi:10.1002/cmdc.201300274

1. ↑ Sato S, Cerny RL, Buescher JL, Ikezu T. Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J Neurochem. 2006 Sep;98(5):1573-84. PMID:16923168 doi:JNC4059