4l60

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Template:STRUCTURE 4l60

Contents

Structure of C81R Mutant PCNA Protein Defective in Mismatch Repair

Template:ABSTRACT PUBMED 23869605

Function

[PCNA_YEAST] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.[1] [2]

About this Structure

4l60 is a 1 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

  • Dieckman LM, Boehm EM, Hingorani MM, Washington MT. Distinct structural alterations in proliferating cell nuclear antigen block DNA mismatch repair. Biochemistry. 2013 Aug 20;52(33):5611-9. doi: 10.1021/bi400378e. Epub 2013 Aug 2. PMID:23869605 doi:10.1021/bi400378e
  1. ↑ Haracska L, Kondratick CM, Unk I, Prakash S, Prakash L. Interaction with PCNA is essential for yeast DNA polymerase eta function. Mol Cell. 2001 Aug;8(2):407-15. PMID:11545742
  2. ↑ Hoege C, Pfander B, Moldovan GL, Pyrowolakis G, Jentsch S. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature. 2002 Sep 12;419(6903):135-41. PMID:12226657 doi:10.1038/nature00991

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