4fl9

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Template:STRUCTURE 4fl9

Crystal Structure of bovine hsc70(aa1-554)E213A/D214A at 1.9A Resolution

Function

[HSP7C_BOVIN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).

About this Structure

4fl9 is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

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