2oot

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Image:2oot.gif

2oot, resolution 1.64Å

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A High Resolution Structure of Ligand-free Human Glutamate Carboxypeptidase II

Contents

Overview

Human glutamate carboxypeptidase II (GCPII; EC 3.4.17.21) is an established marker for prostate-cancer diagnosis as well as a candidate therapeutic target for the treatment of diverse pathologies that involve glutamatergic transmission. Structural data on GCPII are thus valuable for the design and optimization of GCPII-specific inhibitors and diagnostic probes. The currently available structure of ligand-free GCPII was refined to a resolution of 3.5 A. This work reports the structure of the protein refined to 1.65 A resolution, with crystallographic values of R = 0.207 and R(free) = 0.228. The new structure extends the resolution appreciably and the new model based on this data shows significant differences when compared with the previously published model.

Disease

Known diseases associated with this structure: Myocardial infarcation, susceptibility to OMIM:[602855]

About this Structure

2OOT is a Single protein structure of sequence from Homo sapiens with , , and as ligands. Active as Glutamate carboxypeptidase II, with EC number 3.4.17.21 Full crystallographic information is available from OCA.

Reference

A high-resolution structure of ligand-free human glutamate carboxypeptidase II., Barinka C, Starkova J, Konvalinka J, Lubkowski J, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Mar 1;63(Pt, 3):150-3. Epub 2007 Feb 13. PMID:17329803

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