4jcj

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Template:STRUCTURE 4jcj

Contents

Crystal structure of Isl1 LIM domains with Ldb1 LIM-interaction domain

Template:ABSTRACT PUBMED 23750000

Function

[ISL1_MOUSE] Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1.

About this Structure

4jcj is a 3 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Gadd MS, Jacques DA, Nisevic I, Craig VJ, Kwan AH, Guss JM, Matthews JM. A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions. J Biol Chem. 2013 Jul 26;288(30):21924-35. doi: 10.1074/jbc.M113.478586. Epub, 2013 Jun 9. PMID:23750000 doi:http://dx.doi.org/10.1074/jbc.M113.478586

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