4kgh

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Template:STRUCTURE 4kgh

Contents

Crystal Structure of human splunc-1 lacking the secretion signal sequence

Template:ABSTRACT PUBMED 24043776

Function

[BPIA1_HUMAN] May be involved in the airway inflammatory response after exposure to irritants. May be associated with tumor progression. May play a role in innate immune responses of the upper airways.[1]

About this Structure

4kgh is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Garland AL, Walton WG, Coakley RD, Tan CD, Gilmore RC, Hobbs CA, Tripathy A, Clunes LA, Bencharit S, Stutts MJ, Betts L, Redinbo MR, Tarran R. Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):15973-15978. Epub 2013 Sep 16. PMID:24043776 doi:http://dx.doi.org/10.1073/pnas.1311999110
  1. ↑ Lindahl M, Stahlbom B, Tagesson C. Identification of a new potential airway irritation marker, palate lung nasal epithelial clone protein, in human nasal lavage fluid with two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight. Electrophoresis. 2001 May;22(9):1795-800. PMID:11425234 doi:<1795::AID-ELPS1795>3.0.CO;2-J 10.1002/1522-2683(200105)22:9<1795::AID-ELPS1795>3.0.CO;2-J

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