4isr

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Template:STRUCTURE 4isr

Contents

Binding domain of Botulinum neurotoxin DC in complex with rat synaptotagmin II

Template:ABSTRACT PUBMED 23932591

Function

[SYT2_RAT] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.

About this Structure

4isr is a 6 chain structure with sequence from Clostridium botulinum. Full crystallographic information is available from OCA.

Reference

  • Berntsson RP, Peng L, Svensson LM, Dong M, Stenmark P. Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II. Structure. 2013 Sep 3;21(9):1602-11. doi: 10.1016/j.str.2013.06.026. Epub 2013, Aug 8. PMID:23932591 doi:http://dx.doi.org/10.1016/j.str.2013.06.026

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