Pre-mRNA-splicing factor

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Template:STRUCTURE 3e9l

Pre-mRNA-splicing factors (Prp) are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing. For details on pre-mRNA-splicing factors see

• Prp8
  
• Prp24
  
• Prp19
  
• Prp40.

3D Structures of pre-mRNA splicing factors

Updated on 10-October-2013

Pre-mRNA-splicing factor 2

3beg – hPrp residues 105-219 + Ser/Thr-protein kinase – human
2o3d – hPrp P33 subunit

Pre-mRNA-splicing factor 3

1x4q – hPrp PWI domain - NMR

Pre-mRNA-splicing factor 3B

3lqv, 2f9d, 2f9j – hPrp residues 377-415 + pre-mRNA branch site protein 14
2fho - hPrp residues 379-424 + spliceosomal protein P14 - NMR
2do5 – hPrp subunit 2 – NMR
1x5t - hPrp subunit 4 – NMR
1x5u - hPrp subunit 4 RNA-binding domain – NMR

Pre-mRNA-splicing factor 8

3sbt, 4ilh – yPrp RNAseH like domain + A1 cistron-splicing factor AAR2 – yeast
4jk7, 4jk9 - yPrp RNAseH like domain
4ilj, 4jk8, 4jka, 4jkb, 4jkc, 4jkd, 4jke, 4jkf, 4jkg, 4jkh - yPrp RNAseH like domain (mutant)
3e66 – yPrp β-finger domain
3e9o, 3e9p - yPrp RNA-binding domain
2p87, 2og4, 3sbg - yPrp C terminal
3zef, 4i43 – yPrp + A1 cistron-splicing factor AAR2
4bgd – yPrp JAB1/MPN domain + pre-mRNA-splicing helicase BRR2
4kit – yPrp JAB1/MPN domain + U5 small nuclear ribonucleoprotein helicase
4bgd – yPrp JAB1/MPN+RNAseH domains + A1 cistron-splicing factor AAR2 + pre-mRNA-splicing helicase BRR2
3lru – hPrp residues 1831-1990
3e9l – hPrp endonuclease domain
3enb - hPrp core domain IV
2p8r – Prp C terminal (mutant) – Caenorhabditis elegans

Pre-mRNA-splicing factor 9

4dgw – yPrp + Prp 21 + Prp 11

Pre-mRNA-splicing factor 11

4dgw – yPrp + Prp 21 + Prp 9

Pre-mRNA-splicing factor 18

2dk4 – hPrp splicing factor motif domain - NMR

Pre-mRNA-splicing factor 19

3lrv – yPrp WD40 domain
2bay – yPrp U-box
1n87 - yPrp U-box - NMR

Pre-mRNA-splicing factor 20

2i2y – Prp RNA-binding domain + RNA – Streptococcus – NMR
2i38 - hPrp RNA-binding domain (mutant) – NMR

Pre-mRNA-splicing factor 21

4dgw – yPrp + Prp 9 + Prp 11

snRNA-associated-splicing factor 24

2l9w – yPrp C terminal – NMR
2kh9 – yPrp residues 115-197 + RNA – NMR
2go9 – yPrp RNA-binding domains – NMR
2ghp - yPrp RNA-binding domains

Pre-mRNA-splicing factor 31

2ozb – hPrp + RNA + tri-snRNP
3siu, 3siv – hPrp + NHP2-like protein + snRNP

Pre-mRNA-splicing factor 40

1o6w – yPrp WW domain – yeast - NMR
2b7e – yPrp FF1 domain - NMR
2kfd – yPrp FF4 domain - NMR

Pre-mRNA-splicing factor 43P

2xau, 3kx2 – yPrp + ADP

Pre-mRNA-splicing factor RBM22

2ytc – yPrp RNA-binding domain - NMR

Pre-mRNA-splicing factor RDS3

2k0a – yPrp - NMR

Pre-mRNA-splicing factor URN1

2juc – yPrp FF domain - NMR