3wfv

From Proteopedia

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Template:STRUCTURE 3wfv

Contents 1 HIV-1 CRF07 gp41 2 Function 3 About this Structure 4 Reference

HIV-1 CRF07 gp41

Template:ABSTRACT PUBMED 24074570

Function

[Q994K2_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).

About this Structure

3wfv is a 1 chain structure with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

• Du J, Xue H, Ma J, Liu F, Zhou J, Shao Y, Qiao W, Liu X. The crystal structure of HIV CRF07 B'/C gp41 reveals a hyper-mutant site in the middle of HR2 heptad repeat. Virology. 2013 Nov;446(1-2):86-94. doi: 10.1016/j.virol.2013.07.024. Epub 2013, Aug 25. PMID:24074570 doi:http://dx.doi.org/10.1016/j.virol.2013.07.024