4i8y

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 4i8y

Contents 1 Structure of the unliganded N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus 2 Function 3 About this Structure 4 Reference

Structure of the unliganded N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus

Template:ABSTRACT PUBMED 23576432

Function

[PLC_STAAE] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.

About this Structure

4i8y is a 1 chain structure with sequence from Staphylococcus aureus subsp. aureus str. newman. Full crystallographic information is available from OCA.

Reference

• Cheng J, Goldstein R, Gershenson A, Stec B, Roberts MF. The cation-pi box is a specific phosphatidylcholine membrane targeting motif. J Biol Chem. 2013 May 24;288(21):14863-73. doi: 10.1074/jbc.M113.466532. Epub, 2013 Apr 10. PMID:23576432 doi:http://dx.doi.org/10.1074/jbc.M113.466532