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4m63

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Template:STRUCTURE 4m63

Contents

Crystal Structure of a Filament-Like Actin Trimer Bound to the Bacterial Effector VopL

Template:ABSTRACT PUBMED 21873984

Function

[ACT1_DROME] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.

About this Structure

4m63 is a 5 chain structure with sequence from Drosophila melanogaster and Vibrio parahaemolyticus bb22op. Full crystallographic information is available from OCA.

Reference

  • Yu B, Cheng HC, Brautigam CA, Tomchick DR, Rosen MK. Mechanism of actin filament nucleation by the bacterial effector VopL. Nat Struct Mol Biol. 2011 Aug 28;18(9):1068-74. doi: 10.1038/nsmb.2110. PMID:21873984 doi:10.1038/nsmb.2110

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OCA

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