2m6g

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Template:STRUCTURE 2m6g

Contents

Solution structure of cis(C2-P3) trans (D5-P6) form of lO959 in water

Template:ABSTRACT PUBMED 24115170

Function

[COW_CONLO] Activates high voltage-activated calcium channels (Cav). This activity is in contrast to other contryphans that inhibit high voltage-gated calcium channels.

About this Structure

2m6g is a 1 chain structure. Full experimental information is available from OCA.

Reference

  • Sonti R, Gowd KH, Rao KN, Ragothama S, Rodriguez A, Perez JJ, Balaram P. Conformational Diversity in Contryphans from Conus Venom: cis-trans Isomerisation and Aromatic/Proline Interactions in the 23-Membered Ring of a 7-Residue Peptide Disulfide Loop. Chemistry. 2013 Nov 4;19(45):15175-89. doi: 10.1002/chem.201301722. Epub 2013 Sep, 23. PMID:24115170 doi:http://dx.doi.org/10.1002/chem.201301722

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