4m4d

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Template:STRUCTURE 4m4d

Contents

Crystal structure of lipopolysaccharide binding protein

Template:ABSTRACT PUBMED 24120359

Function

[LBP_MOUSE] Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity).

About this Structure

4m4d is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Eckert JK, Kim YJ, Kim JI, Gurtler K, Oh DY, Sur S, Lundvall L, Hamann L, van der Ploeg A, Pickkers P, Giamarellos-Bourboulis E, Kubarenko AV, Weber AN, Kabesch M, Kumpf O, An HJ, Lee JO, Schumann RR. The Crystal Structure of Lipopolysaccharide Binding Protein Reveals the Location of a Frequent Mutation that Impairs Innate Immunity. Immunity. 2013 Oct 17;39(4):647-60. doi: 10.1016/j.immuni.2013.09.005. Epub 2013 , Oct 10. PMID:24120359 doi:http://dx.doi.org/10.1016/j.immuni.2013.09.005

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