4hsc
From Proteopedia
Crystal structure of a cholesterol dependent cytolysin
Function
[TACY_STRPQ] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).
About this Structure
4hsc is a 1 chain structure with sequence from Streptococcus pyogenes ssi-1. Full crystallographic information is available from OCA.
