LaurenJansen/Sandbox1

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Contents 1 Membrane Type 1 Matrix Metalloproteinase 1.1 Structure 1.2 Inhibition 1.3 Extracellular Matrix Components 1.4 See Also 1.5 References

Membrane Type 1 Matrix Metalloproteinase

One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.

Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) is 1 of ~21 members of the human MMP family of endopeptidases. MMPs are zinc dependent proteinases that are capable of degrading virtually any extracellular matrix component. Inherently, this enables MMPs to be a key player in regulation of cell behavior.

There are 8 structure classes for MMPs, of which 5 are secreted molecules and 3 are membrane-type. MT1-MMP or also known as MMP-14 is covalently bound to the cell membrane and

spinqualitylabelsall models PBD file obtained from http://pdb.org/pdb/explore/explore.do?structureId=1bqq Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

UMASS

spinqualitylabelsall models PBD file obtained from http://pdb.org/pdb/explore/explore.do?structureId=1bqq Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Structure

Inhibition

Extracellular Matrix Components

See Also

References

1. M. Sternlicht, et al., How Matrix Metalloproteinases Regulate Cell Behavior, Annu Rev Cell Dev Biol, 2001. 17: p. 463–516.

2. L. Coussens, et al., Meatrix Metalloproteinase Inhibitors and Cancer: Trials and Tribulations