LaurenJansen/Sandbox1

From Proteopedia

proteopedia linkproteopedia link

Contents 1 Membrane Type 1 Matrix Metalloproteinase 2 Structure 3 Inhibition 4 Extracellular Matrix Components

Membrane Type 1 Matrix Metalloproteinase

One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground. Molecular Playground banner: "MMP-14 allows for 3D in vitro cell migration"

Structure

Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) is 1 of ~21 members of the human MMP family of endopeptidases. MMPs are zinc dependent proteinases that are capable of degrading virtually any extracellular matrix component. Inherently, this enables MMPs to be a key player in regulation of cell behavior.

There are 8 structure classes for MMPs, of which 5 are secreted molecules and 3 are membrane-type. MT1-MMP or also known as MMP-14 is covalently bound to the cell membrane and

spinqualitylabelsall models PBD file obtained from http://pdb.org/pdb/explore/explore.do?structureId=1bqq Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Inhibition

spinqualitylabelsall models PBD file obtained from http://pdb.org/pdb/explore/explore.do?structureId=1bqq Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Extracellular Matrix Components

^[1]