4a4h

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Template:STRUCTURE 4a4h

Contents 1 Solution structure of SPF30 Tudor domain in complex with asymmetrically dimethylated arginine 2 Function 3 About this Structure 4 Reference

Solution structure of SPF30 Tudor domain in complex with asymmetrically dimethylated arginine

Template:ABSTRACT PUBMED 22101937

Function

[SPF30_HUMAN] Necessary for spliceosome assembly. Overexpression causes apoptosis.^{[1] [2] [3]}

About this Structure

4a4h is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

• Tripsianes K, Madl T, Machyna M, Fessas D, Englbrecht C, Fischer U, Neugebauer KM, Sattler M. Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins. Nat Struct Mol Biol. 2011 Nov 20. doi: 10.1038/nsmb.2185. PMID:22101937 doi:10.1038/nsmb.2185

1. ↑ Talbot K, Miguel-Aliaga I, Mohaghegh P, Ponting CP, Davies KE. Characterization of a gene encoding survival motor neuron (SMN)-related protein, a constituent of the spliceosome complex. Hum Mol Genet. 1998 Dec;7(13):2149-56. PMID:9817934
2. ↑ Meister G, Hannus S, Plottner O, Baars T, Hartmann E, Fakan S, Laggerbauer B, Fischer U. SMNrp is an essential pre-mRNA splicing factor required for the formation of the mature spliceosome. EMBO J. 2001 May 1;20(9):2304-14. PMID:11331595 doi:http://dx.doi.org/10.1093/emboj/20.9.2304
3. ↑ Rappsilber J, Ajuh P, Lamond AI, Mann M. SPF30 is an essential human splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. J Biol Chem. 2001 Aug 17;276(33):31142-50. Epub 2001 Apr 30. PMID:11331295 doi:http://dx.doi.org/10.1074/jbc.M103620200