4m67

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Template:STRUCTURE 4m67

Contents 1 Crystal structure of the human MLKL kinase-like domain 2 Function 3 About this Structure 4 Reference

Crystal structure of the human MLKL kinase-like domain

Template:ABSTRACT PUBMED 24095729

Function

[MLKL_HUMAN] Required for the execution of programmed necrosis.^[1]

About this Structure

4m67 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Xie T, Peng W, Yan C, Wu J, Gong X, Shi Y. Structural Insights into RIP3-Mediated Necroptotic Signaling. Cell Rep. 2013 Oct 17;5(1):70-8. doi: 10.1016/j.celrep.2013.08.044. Epub 2013 Oct, 3. PMID:24095729 doi:http://dx.doi.org/10.1016/j.celrep.2013.08.044

1. ↑ Wang Z, Jiang H, Chen S, Du F, Wang X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell. 2012 Jan 20;148(1-2):228-43. doi: 10.1016/j.cell.2011.11.030. PMID:22265414 doi:http://dx.doi.org/10.1016/j.cell.2011.11.030