4m4z

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Template:STRUCTURE 4m4z

Contents

SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)

Template:ABSTRACT PUBMED 24018043

Function

[SLAP2_HUMAN] Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

About this Structure

4m4z is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Wybenga-Groot LE, McGlade CJ. Crystal structure of Src-like adaptor protein 2 reveals close association of SH3 and SH2 domains through beta-sheet formation. Cell Signal. 2013 Dec;25(12):2702-8. doi: 10.1016/j.cellsig.2013.08.040. Epub, 2013 Sep 7. PMID:24018043 doi:http://dx.doi.org/10.1016/j.cellsig.2013.08.040

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