3g60

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Template:STRUCTURE 3g60

Contents 1 Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding 2 Function 3 About this Structure 4 Reference

Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

Template:ABSTRACT PUBMED 19325113

Function

[MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.^[1]

About this Structure

3g60 is a 2 chain structure with sequence from Lk3 transgenic mice. The March 2010 RCSB PDB Molecule of the Month feature on P-glycoprotein by David Goodsell is 10.2210/rcsb_pdb/mom_2010_3. Full crystallographic information is available from OCA.

Reference

• Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science. 2009 Mar 27;323(5922):1718-22. PMID:19325113 doi:323/5922/1718

1. ↑ Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science. 2009 Mar 27;323(5922):1718-22. PMID:19325113 doi:323/5922/1718